YAP is essential for 3D organogenesis withstanding gravity
نویسندگان
چکیده
منابع مشابه
CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation.
The Yes-associated protein, YAP, is a downstream effector of the Hippo pathway of cell-cycle control that plays important roles in tumorigenesis. Hippo-mediated phosphorylation YAP, mainly at S127, inactivates YAP function. In this study, we define a mechanism for positive regulation of YAP activity that is critical for its oncogenic function. Specifically, we found that YAP is phosphorylated i...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2017
ISSN: 0012-1592
DOI: 10.1111/dgd.12338